What's the Best Pain Reliever? (2024)

Most are safe and effective when taken properly

What's the Best Pain Reliever? (1)

Most are safe and effective when taken properly

It can be overwhelming deciding which over the counter (OTC) pain medicine to take for different aches and pains. There are many to choose from at your local drug store. The most appropriate usually depends on the type of pain you’re experiencing and your health.

Most nonprescription pain medicines are good at reducing pain as a symptom when taken for short periods and as recommended. But caution should still be taken.

“With any of these pain relievers, always read the labels and discuss any questions about dosage, safety, or prescription interactions with your doctor,” says David Miller, MD, a family medicine physician at Scripps Clinic Rancho Bernardo.

Contact your physician also if your pain reliever isn’t working for you. Your physician can check for any underlying condition that might be causing your symptoms.

Types of pain

OTC pain relief medications can help provide relief for different types of acute pain.

The Centers for Disease Control and Prevention defines acute pain as pain that has lasted for less than a month and has a known cause, such as an injury, trauma, surgery or infection.

Chronic pain, which is pain lasting three months or more, can also be managed with OTC pain medicines.

Types of OTC pain relievers

The two main types of OTC pain relievers are acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs). They work differently on the body.

Acetaminophen blocks pain messages in the brain. NSAIDs, which include aspirin, ibuprofen and naproxen, work by reducing the level of chemicals involved in inflammation.

Acetaminophen

Acetaminophen (Tylenol) is a used to relieve mild to moderate pain. It is particularly effective for treating headaches and reducing fevers.

“Acetaminophen is often the OTC pain reliever I recommend first for minor ailments,” Dr. Miller says.

See Also
NSAIDs

“It is very safe when taken appropriately and is less likely to cause stomach irritation than an NSAID. Pregnant women can take it, as well as the very young, including infants and children with fever.”

As with any medication, follow instructions and stay within the daily limit allowed. Be careful not to take too much without knowing it. Acetaminophen can be found in many cough and cold products, including NyQuil and TheraFlu. Taking too much acetaminophen can harm your liver, perhaps permanently.

Aspirin

Aspirin (Bayer, Bufferin) is one of the oldest pain relievers, used to reduce pain, swelling and fever. It is also used to help prevent blood clots.

Aspirin, an NSAID, is not recommended for everyone and should always be taken as directed.

Aspirin may cause side effects, including nausea, vomiting, stomach pain and heartburn. Physicians nowadays recommend other more effective pain relievers.

Aspirin should not be given to children and teens as it has been linked to an increased risk of Reye’s syndrome, a rare but serious condition that causes swelling in the liver and brain.

“Adolescents and children should never be given aspirin for flu-like symptoms, chickenpox and other viral illnesses due to the risk of Reye’s syndrome,” says Dr. Miller.

Aspirin has special benefits for people with heart disease. It is widely used to help prevent and manage heart disease and stroke in people with a high risk.

Aspirin thins out platelets, the cells responsible for blood clots, which can contribute to strokes and heart attacks. Clotting can clog the arteries supplying the heart and brain. Other NSAIDs are not recommended for people with heart disease, high blood pressure or other risk factors.

Ibuprofen

Ibuprofen (Advil, Motrin) is an NSAID that can be used to treat pain and inflammation and reduce fever. It may be more effective for some symptoms or conditions, depending on the type of pain.

“I often recommend ibuprofen for menstrual cramps and sore muscles,” explains Dr. Miller.

“Ibuprofen is less of a stomach irritant than aspirin and has less of a blood-thinning effect if you have any conditions where loss of platelets would be a concern,” he says. “However, it’s important to note there have been some concerns that ibuprofen can contribute to kidney damage if not used correctly.”

Naproxen

Naproxen (Aleve) is the most powerful anti-inflammatory pain reliever available without a prescription. It is especially effective for sprains, sunburns and arthritis and other conditions.

Similar doses of Naproxen tend to last longer than other non-prescription pain relievers. They can last eight to 12 hours, compared to four to eight hours. Fewer tablets can be taken during the day.

Naproxen is not recommended for people over 65. Older adults are more likely to have side effects, such as ulcers and bleeding.

What's the Best Pain Reliever? (2024)

FAQs

What is the most effective pain reliever? ›

Naproxen (Aleve) is the most powerful anti-inflammatory pain reliever available without a prescription. It is especially effective for sprains, sunburns and arthritis and other conditions. Similar doses of Naproxen tend to last longer than other non-prescription pain relievers.

What is the best pain relief you can buy over-the-counter? ›

Paracetamol is the most common analgesic (painkiller) you can buy. It is recommended for the treatment of mild pain and comes in tablet, capsule, syrup and soluble forms. Another option is a non-steroidal anti-inflammatory (NSAID) preparation, such as ibuprofen. NSAIDs relieve mild pain and reduce swelling.

What is best for extreme pain? ›

Opioid medicines, such as codeine, morphine and oxycodone – these medicines are reserved for severe or cancer pain. Local anaesthetics (drops, sprays, creams or injections) – used when nerves can be easily reached.

Which painkiller works the fastest? ›

IV morphine, for example, acts the fastest. Within 5–10 minutes , a person can feel pain relief. Intramuscular injections take a little longer, between 10 and 30 minutes. Oral opioids may take about 30 minutes before they start working.

What is the strongest anti-inflammatory painkiller? ›

Naproxen (Aleve) is the strongest NSAID available without a prescription. Pain relief lasts longer, so you do not have to take it as often as ibuprofen (Advil).

What is the safest pain reliever for seniors? ›

Acetaminophen (Tylenol) is usually safer for older adults than other pain medicines. Topical pain medicines (also called topical analgesics) can also help. When common pain medicines don't work to manage pain, your healthcare provider may suggest other medicines, such as antidepressants or anticonvulsants.

What is the best pain reliever that is not a narcotic? ›

What are some alternatives to opioids? There are many non-opioid pain medications that are available over the counter or by prescription, such as ibuprofen (Motrin), acetaminophen (Tylenol), aspirin (Bayer), and steroids, and some patients find that these are all they need.

What is the strongest medication for severe back pain? ›

Narcotic Pain Medications

If you experience severe pain, your health provider might prescribe a narcotic pain medication such as codeine and morphine. Narcotics relieve pain by acting as a numbing anesthetic to the central nervous system.

What is a drug that relieves pain only? ›

Analgesics, also called painkillers, are medications that relieve different types of pain — from headaches to injuries to arthritis. Anti-inflammatory analgesics reduce inflammation, and opioid analgesics change the way the brain perceives pain.

What can you do for extreme pain? ›

10 ways to reduce pain
  1. Get some gentle exercise. ...
  2. Breathe right to ease pain. ...
  3. Read books and leaflets on pain. ...
  4. Talking therapies can help with pain. ...
  5. Distract yourself. ...
  6. Share your story about pain. ...
  7. The sleep cure for pain. ...
  8. Take a course.

How do I stop unbearable pain? ›

Relaxation, meditation, positive thinking, and other mind-body techniques can help reduce your need for pain medication. Drugs are very good at getting rid of pain, but they often have unpleasant, and even serious, side effects when used for a long time.

How can I get instant relief from pain? ›

Cold and heat.

These two tried-and-true methods are still the cornerstone of relieving pain for certain kinds of injuries. If a homemade hot or cold pack doesn't do the trick, try asking a physical therapist or chiropractor for their versions of these treatments, which can penetrate deeper into the muscle and tissue.

Which is stronger, oxycodone or hydrocodone? ›

Is there a difference between hydrocodone and oxycodone? One key difference is that oxycodone is more potent than hydrocodone. This means that it takes less oxycodone to produce the same effects as hydrocodone. Oxycodone is also more likely to be abused than hydrocodone because it produces stronger effects.

Can I take 2 Tylenol and 1 ibuprofen together? ›

You can take ibuprofen and acetaminophen at the same time. Just make sure to not take more than the recommended dose. Some people experience some stomach or abdominal pain when taking the two medications together. In this case, it's better to alternate when you take each medication.

Why do I still feel pain after taking painkillers? ›

Opioids do provide relief by blocking pain. But as a result, your body reacts by increasing the number of receptors to try to get the pain signal through again. So when the drug wears off, you will experience more pain for about three days.

Is Tylenol or ibuprofen better for pain? ›

While acetaminophen only works in the brain, ibuprofen works in the brain and the rest of the body. This means acetaminophen only helps reduce pain and fever, while ibuprofen has the added benefit of reducing inflammation and swelling at the site of an injury.

What is a strong painkiller for back pain? ›

Your doctor may also prescribe a medicine called an opioid for lower back pain. Weak opioids (such as codeine) may be given for moderate pain. For severe and persistent pain, you may need stronger opioids, such as morphine. You might have this with or without paracetamol.

Is Aleve better than ibuprofen? ›

Ibuprofen is short-acting and is better suited for the treatment of acute pain, whereas Aleve is long-acting and is used for the treatment of chronic conditions. Aleve is more likely than ibuprofen to cause gastrointestinal (GI) side effects because it is longer acting.

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